"About Cell Therapeutics Cancer Research, Cancer Therapies, and Cancer Drug Development"

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cellspacing="0" cellpadding="0"> <tr> <td valign="top" class="a"> <h2>Making Cancer More Treatable</h2><h1>A Commitment to More Effective Cancer Treatments and Cancer Drugs</h1> As CTI's <a href="abou_frame-glos.htm#cancer">cancer</a> drugs progress through <a href="abou_frame-glos.htm#phaseI">clinical trials</a> to commercialization, our commitment to patients and the real issues of their cancer treatments grows stronger. The challenge to overcome the therapeutic limitations of cancer treatment provides us with a focus and sense of urgency. <br> <br> <h1>Targeting the Side Effects and Toxicities of Conventional Cancer Therapies</h1> Today, more than 9.2 million Americans have cancer, and one in three people in North America and Europe will develop cancer at some point in their lifetime. At the time of diagnosis, 70 percent of patients have <a href="abou_frame-glos.htm#tumor">tumors</a> that have already spread to other parts of their body. So, almost all receive systemic therapy such as <a href="abou_frame-glos.htm#chemotherapy">chemotherapy</a> during the course of their disease. <br> <br> Despite recent advances in sequencing the <a href="abou_frame-glos.htm#humangenome">human genome</a> and the introduction of new biologic therapies for the treatment of cancer, almost all patients with advanced cancer will receive chemotherapy at some point during the treatment of their disease. Four classes of chemotherapy agents — <a href="abou_frame-glos.htm#anthracyclines">anthracyclines</a>, <a href="abou_frame-glos.htm#camptothecins">camptothecins</a>, <a href="abou_frame-glos.htm#platinum">platinates</a>, and <a href="abou_frame-glos.htm#taxanes">taxanes</a> — account for more than 95% of all chemotherapy cancer drug usage. Unfortunately, there are significant limitations and complications associated with these agents that result in a high rate of treatment failure. The principal limitations of chemotherapy in treating cancer include:</p> <ul> <li> Treatment related toxicities</li> <li>Inability to selectively target tumor tissue</li> <li>The development of resistance to the cancer-killing effects of chemotherapy<br> </li> </ul> <h1>Overcoming the Limitations of Current Cancer Treatment</h1> We believe next generation cancer treatment agents that have lower toxicity and/or increased effectiveness than these cornerstone chemotherapy classes address a significant unmet need for the majority of cancer patients in the U.S. and Europe. Our cancer drug development <a href="abou_frame-glos.htm#pipeline">pipeline</a> includes a next generation drug candidate for each of the four leading classes of chemotherapy agents. <br> <br> We presently have two products in late-stage clinical developmentXYOTAX and pixantrone, and a robust product pipeline. Our capabilities span drug development through commercialization. Founded in 1991, our headquarters is in Seattle, Washington with research and development facilities in Seattle and Bresso (Milan), Italy. <br> <br> If you'd like to be alerted by email when company news is released, sign up for <a href="investors_alert.htm" target="_parent">email alerts</a>. <br> <br> <br> <font class="cr">Posted July 18, 2005</font><br> <br> <font class="cr">Copyright © 2004, 2005 Cell Therapeutics, Inc., Seattle, WA, USA. All rights reserved. "Making cancer more treatable" is a registered mark of CTI. </font> <br>   </td> </tr> </table> </td> <td> </td> </tr> <tr> <td width="65"><img src="images/0.gif" width="65" height="5" alt="" border="0"></td> <td width="1"><img src="images/0.gif" width="1" height="5" alt="" border="0"></td> <td width="202"><img src="images/0.gif" width="202" height="5" alt="" border="0"></td> <td width="1"><img src="images/0.gif" width="1" height="5" alt="" border="0"></td> <td width="50"><img src="images/0.gif" width="50" height="5" alt="" border="0"></td> <td width="100%"><img src="images/0.gif" width="400" height="5" alt="" border="0"></td> <td width="50"><img src="images/0.gif" width="50" height="5" alt="" border="0"></td> </tr> </table> </body>